Principal Investigators
Peter Rogan, Ph.D. (progan {@} aya.yale.edu), Director of the Laboratory of Human Molecular Genetics, is a Professor in
Biochemistry s at the University of Western Ontario, Schulich School of
Medicine.
(SCE). Dr.
Rogan is a molecular biologist with a strong record of accomplishments
in human genetics and computational molecular biology. He has
made significant contributions to the study of genotype-phenotype
relationships in a variety of inherited and imprinted disorders, and,
together with Dr. Thomas Schneider, proposed and applied the concept of
information analysis to the systematic analysis of human
mutations. Dr. Rogan has established an independent and
continuous record of accomplishments in several areas including
computational biology, image processing of molecular biological data,
genetic database construction, linkage analysis, molecular evolution,
and cytogenomics.
Joan Knoll, Ph.D., (jknoll {@} umalumni.mb.ca), Director of the Laboratory of
Genomic Disorders, is Professor in
Pathology at the University of Western Ontario, Schulich School of Medicine
and is board certified by the American College of Medical Genetics
in Cytogenetics and Molecular Genetics. She has directed clinical cytogenetics
laboratories at several academic research institutions since 1991.
Dr. Knoll authored the first article describing in
situ hybridization (ISH) in Current Protocols in Human Genetics, a
primary reference for genetics laboratories worldwide; has developed
numerous improvements in ISH since the late 1980's; and most recently
has co-invented with Dr. Rogan a method of developing single copy DNA
probes from the human genome sequence and using these probes for
FISH. She is currently directing an NCI funded project to precisely define
chromosome abnormalities in chronic myelogenous leukemia.