Gene: WFS1
mRNA Accession: AF084481
Mutation:WFS1.txt
Chromosome: chr 4

Sequence Walker  


No Change of Information Content
Mutation SubmittedMutation InstructionGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
c.376G>A
Sequence Walker   		g6283501a 6283530 90 6283440 0.0 0.0 0.0 1.0 100 -1.9 -1.9 0.0
c.376G>A
Sequence Walker   		g6283501a 6283533 93 6283440 1.8 1.8 0.0 1.0 100 -1.6 -1.6 0.0
c.631G>A
Sequence Walker   		g6285821a 6285864 42 6285822 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
c.874C>T
Sequence Walker   		c6295123t 6295110 0 6295110 11.4 11.4 0.0 1.0 100 0.6 0.6 0.0
c.874C>T
Sequence Walker   		c6295123t 6295175 65 6295110 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
c.887T>G
Sequence Walker   		t6295136g 6295110 0 6295110 11.4 11.4 0.0 1.0 100 0.6 0.6 0.0
c.887T>G
Sequence Walker   		t6295136g 6295175 65 6295110 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
c.887T>G
Sequence Walker   		t6295136g 6295180 70 6295110 1.8 1.8 0.0 1.0 100 -1.6 -1.6 0.0
c.1046_1048delTCT
Sequence Walker   		d6295295,6295297 6295283 173 6295110 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
c.1046_1048delTCT
Sequence Walker   		d6295295,6295297 6295287 177 6295110 4.6 4.6 0.0 1.0 100 -0.9 -0.9 0.0
c.1046_1048delTCT
Sequence Walker   		d6295295,6295297 6295290 180 6295110 7.5 7.5 0.0 1.0 100 -0.3 -0.3 0.0
c.1046_1048delTCT
Sequence Walker   		d6295295,6295297 6295338 228 6295110 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0
c.1046_1048delTCT
Sequence Walker   		d6295295,6295297 6295347 237 6295110 4.1 4.1 0.0 1.0 100 -1.0 -1.0 0.0
c.1060_1062delTTC
Sequence Walker   		d6295309,6295311 6295283 173 6295110 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
c.1060_1062delTTC
Sequence Walker   		d6295309,6295311 6295287 177 6295110 4.6 4.6 0.0 1.0 100 -0.9 -0.9 0.0
c.1060_1062delTTC
Sequence Walker   		d6295309,6295311 6295290 180 6295110 7.5 7.5 0.0 1.0 100 -0.3 -0.3 0.0
c.1060_1062delTTC
Sequence Walker   		d6295309,6295311 6295302 192 6295110 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0
c.1060_1062delTTC
Sequence Walker   		d6295309,6295311 6295338 228 6295110 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0
c.1060_1062delTTC
Sequence Walker   		d6295309,6295311 6295347 237 6295110 4.1 4.1 0.0 1.0 100 -1.0 -1.0 0.0
c.1240_1242delTTC
Sequence Walker   		d6295489,6295491 6295483 373 6295110 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
c.1240_1242delTTC
Sequence Walker   		d6295489,6295491 6295513 403 6295110 4.0 4.0 0.0 1.0 100 -1.1 -1.1 0.0
c.1240_1242delTTC
Sequence Walker   		d6295489,6295491 6295517 407 6295110 9.2 9.2 0.0 1.0 100 0.1 0.1 0.0
c.1240_1242delTTC
Sequence Walker   		d6295489,6295491 6295520 410 6295110 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
c.1240_1242delTTC
Sequence Walker   		d6295489,6295491 6295521 411 6295110 4.0 4.0 0.0 1.0 100 -1.1 -1.1 0.0
c.1243_1245delGTC
Sequence Walker   		d6295492,6295494 6295483 373 6295110 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
c.1243_1245delGTC
Sequence Walker   		d6295492,6295494 6295520 410 6295110 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
c.1243_1245delGTC
Sequence Walker   		d6295492,6295494 6295521 411 6295110 4.0 4.0 0.0 1.0 100 -1.1 -1.1 0.0
c.1309G>C
Sequence Walker   		g6295558c 6295603 493 6295110 2.2 2.2 0.0 1.0 100 -1.5 -1.5 0.0
c.1328G>T
Sequence Walker   		g6295577t 6295603 493 6295110 2.2 2.2 0.0 1.0 100 -1.5 -1.5 0.0
c.1328G>T
Sequence Walker   		g6295577t 6295619 509 6295110 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
c.1511C>T
Sequence Walker   		c6295760t 6295754 644 6295110 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
c.1511C>T
Sequence Walker   		c6295760t 6295799 689 6295110 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0
c.1511C>T
Sequence Walker   		c6295760t 6295802 692 6295110 6.1 6.1 0.0 1.0 100 -0.6 -0.6 0.0
c.1511C>T
Sequence Walker   		c6295760t 6295803 693 6295110 1.0 1.0 0.0 1.0 100 -1.7 -1.7 0.0
c.1511C>T
Sequence Walker   		c6295760t 6295804 694 6295110 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
c.1511C>T
Sequence Walker   		c6295760t 6295807 697 6295110 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
c.1511C>T
Sequence Walker   		c6295760t 6295809 699 6295110 6.7 6.7 0.0 1.0 100 -0.5 -0.5 0.0
c.1514G>A
Sequence Walker   		g6295763a 6295754 644 6295110 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
c.1514G>A
Sequence Walker   		g6295763a 6295799 689 6295110 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0
c.1514G>A
Sequence Walker   		g6295763a 6295802 692 6295110 6.1 6.1 0.0 1.0 100 -0.6 -0.6 0.0
c.1514G>A
Sequence Walker   		g6295763a 6295803 693 6295110 1.0 1.0 0.0 1.0 100 -1.7 -1.7 0.0
c.1514G>A
Sequence Walker   		g6295763a 6295804 694 6295110 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
c.1514G>A
Sequence Walker   		g6295763a 6295807 697 6295110 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
c.1514G>A
Sequence Walker   		g6295763a 6295809 699 6295110 6.7 6.7 0.0 1.0 100 -0.5 -0.5 0.0
c.1620_1622delGTG
Sequence Walker   		d6295869,6295871 6295854 744 6295110 2.7 2.7 0.0 1.0 100 -1.3 -1.3 0.0
c.1620_1622delGTG
Sequence Walker   		d6295869,6295871 6295896 786 6295110 0.4 0.4 0.0 1.0 100 -1.9 -1.9 0.0
c.1628T>G
Sequence Walker   		t6295877g 6295854 744 6295110 2.7 2.7 0.0 1.0 100 -1.3 -1.3 0.0
c.1673G>A
Sequence Walker   		g6295922a 6295896 786 6295110 0.4 0.4 0.0 1.0 100 -1.9 -1.9 0.0
c.1673G>A
Sequence Walker   		g6295922a 6295954 844 6295110 2.4 2.4 0.0 1.0 100 -1.4 -1.4 0.0
c.1673G>A
Sequence Walker   		g6295922a 6295962 852 6295110 2.1 2.1 0.0 1.0 100 -1.5 -1.5 0.0
c.1673G>A
Sequence Walker   		g6295922a 6295964 854 6295110 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0
c.1673G>A
Sequence Walker   		g6295922a 6295968 858 6295110 7.1 7.1 0.0 1.0 100 -0.4 -0.4 0.0
c.1673G>A
Sequence Walker   		g6295922a 6295969 859 6295110 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
c.1820C>G
Sequence Walker   		c6296069g 6296063 953 6295110 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0
c.2006A>G
Sequence Walker   		a6296255g 6296250 1140 6295110 3.1 3.1 0.0 1.0 100 -1.3 -1.3 0.0
c.2051C>T
Sequence Walker   		c6296300t 6296331 1221 6295110 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
c.2051C>T
Sequence Walker   		c6296300t 6296339 1229 6295110 0.6 0.6 0.0 1.0 100 -1.8 -1.8 0.0
c.2084G>T
Sequence Walker   		g6296333t 6296321 1211 6295110 3.1 3.1 0.0 1.0 100 -1.3 -1.3 0.0
c.2100G>T
Sequence Walker   		g6296349t 6296321 1211 6295110 3.1 3.1 0.0 1.0 100 -1.3 -1.3 0.0
c.2100G>T
Sequence Walker   		g6296349t 6296331 1221 6295110 1.6 1.6 0.0 1.0 100 -1.6 -1.6 0.0
c.2100G>T
Sequence Walker   		g6296349t 6296339 1229 6295110 0.6 0.6 0.0 1.0 100 -1.8 -1.8 0.0
c.2149G>A
Sequence Walker   		g6296398a 6296431 1321 6295110 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
c.2206G>A
Sequence Walker   		g6296455a 6296431 -1289 6297720 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
c.2378G>C
Sequence Walker   		g6296627c 6296603 -1117 6297720 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
c.2452C>T
Sequence Walker   		c6296701t 6296739 -981 6297720 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0
c.406C>T
Sequence Walker   		c6283531t 6283580 -6 6283586 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0
c.676C>T
Sequence Walker   		c6286415t 6286411 -41 6286452 4.9 4.9 0.0 1.0 100 -0.9 -0.9 0.0
c.817G>T
Sequence Walker   		g6289599t 6289580 -64 6289644 9.5 9.5 0.0 1.0 100 0.1 0.1 0.0
c.817G>T
Sequence Walker   		g6289599t 6289643 -1 6289644 2.4 2.4 0.0 1.0 100 -1.4 -1.4 0.0
c.1038_1039insC
Sequence Walker   		i6295287,6295288c 6295283 173 6295110 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
c.1038_1039insC
Sequence Walker   		i6295287,6295288c 6295313 203 6295110 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
c.1038_1039insC
Sequence Walker   		i6295287,6295288c 6295319 209 6295110 5.1 5.1 0.0 1.0 100 -0.8 -0.8 0.0
c.1038_1039insC
Sequence Walker   		i6295287,6295288c 6295320 210 6295110 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
c.1038_1039insC
Sequence Walker   		i6295287,6295288c 6295321 211 6295110 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
c.1038_1039insC
Sequence Walker   		i6295287,6295288c 6295338 228 6295110 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0
c.1096C>T
Sequence Walker   		c6295345t 6295319 209 6295110 5.1 5.1 0.0 1.0 100 -0.8 -0.8 0.0
c.1096C>T
Sequence Walker   		c6295345t 6295320 210 6295110 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
c.1096C>T
Sequence Walker   		c6295345t 6295321 211 6295110 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
c.1096C>T
Sequence Walker   		c6295345t 6295338 228 6295110 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0
c.1112G>A
Sequence Walker   		g6295361a 6295338 228 6295110 4.8 4.8 0.0 1.0 100 -0.9 -0.9 0.0
c.1112G>A
Sequence Walker   		g6295361a 6295347 237 6295110 4.1 4.1 0.0 1.0 100 -1.0 -1.0 0.0
c.1112G>A
Sequence Walker   		g6295361a 6295404 294 6295110 0.9 0.9 0.0 1.0 100 -1.7 -1.7 0.0
c.1230_1233delCTCT
Sequence Walker   		d6295479,6295482 6295509 399 6295110 0.9 0.9 0.0 1.0 100 -1.7 -1.7 0.0
c.1230_1233delCTCT
Sequence Walker   		d6295479,6295482 6295511 401 6295110 4.6 4.6 0.0 1.0 100 -0.9 -0.9 0.0
c.1230_1233delCTCT
Sequence Walker   		d6295479,6295482 6295513 403 6295110 4.0 4.0 0.0 1.0 100 -1.1 -1.1 0.0
c.1230_1233delCTCT
Sequence Walker   		d6295479,6295482 6295517 407 6295110 9.2 9.2 0.0 1.0 100 0.1 0.1 0.0
c.1230_1233delCTCT
Sequence Walker   		d6295479,6295482 6295520 410 6295110 2.3 2.3 0.0 1.0 100 -1.4 -1.4 0.0
c.1230_1233delCTCT
Sequence Walker   		d6295479,6295482 6295521 411 6295110 4.0 4.0 0.0 1.0 100 -1.1 -1.1 0.0
c.1362_1377del16
Sequence Walker   		d6295611,6295626 6295603 493 6295110 2.2 2.2 0.0 1.0 100 -1.5 -1.5 0.0
c.1380_1388del9
Sequence Walker   		d6295629,6295637 6295603 493 6295110 2.2 2.2 0.0 1.0 100 -1.5 -1.5 0.0
c.1380_1388del9
Sequence Walker   		d6295629,6295637 6295619 509 6295110 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
c.1456C>T
Sequence Walker   		c6295705t 6295695 585 6295110 4.6 4.6 0.0 1.0 100 -0.9 -0.9 0.0
c.1456C>T
Sequence Walker   		c6295705t 6295754 644 6295110 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
c.1522_1536del15
Sequence Walker   		d6295771,6295785 6295754 644 6295110 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
c.1522_1536del15
Sequence Walker   		d6295771,6295785 6295804 694 6295110 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
c.1522_1536del15
Sequence Walker   		d6295771,6295785 6295807 697 6295110 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
c.1522_1536del15
Sequence Walker   		d6295771,6295785 6295809 699 6295110 6.7 6.7 0.0 1.0 100 -0.5 -0.5 0.0
c.1523_1524delAT
Sequence Walker   		d6295772,6295773 6295754 644 6295110 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
c.1523_1524delAT
Sequence Walker   		d6295772,6295773 6295799 689 6295110 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0
c.1523_1524delAT
Sequence Walker   		d6295772,6295773 6295802 692 6295110 6.1 6.1 0.0 1.0 100 -0.6 -0.6 0.0
c.1523_1524delAT
Sequence Walker   		d6295772,6295773 6295803 693 6295110 1.0 1.0 0.0 1.0 100 -1.7 -1.7 0.0
c.1523_1524delAT
Sequence Walker   		d6295772,6295773 6295804 694 6295110 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
c.1523_1524delAT
Sequence Walker   		d6295772,6295773 6295807 697 6295110 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
c.1523_1524delAT
Sequence Walker   		d6295772,6295773 6295809 699 6295110 6.7 6.7 0.0 1.0 100 -0.5 -0.5 0.0
c.1525_1537del13
Sequence Walker   		d6295774,6295786 6295754 644 6295110 2.0 2.0 0.0 1.0 100 -1.5 -1.5 0.0
c.1558C>T
Sequence Walker   		c6295807t 6295799 689 6295110 3.8 3.8 0.0 1.0 100 -1.1 -1.1 0.0
c.1558C>T
Sequence Walker   		c6295807t 6295802 692 6295110 6.1 6.1 0.0 1.0 100 -0.6 -0.6 0.0
c.1558C>T
Sequence Walker   		c6295807t 6295803 693 6295110 1.0 1.0 0.0 1.0 100 -1.7 -1.7 0.0
c.1558C>T
Sequence Walker   		c6295807t 6295804 694 6295110 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
c.1558C>T
Sequence Walker   		c6295807t 6295854 744 6295110 2.7 2.7 0.0 1.0 100 -1.3 -1.3 0.0
c.1581_1582insC
Sequence Walker   		i6295830,6295831c 6295802 692 6295110 6.1 6.1 0.0 1.0 100 -0.6 -0.6 0.0
c.1581_1582insC
Sequence Walker   		i6295830,6295831c 6295803 693 6295110 1.0 1.0 0.0 1.0 100 -1.7 -1.7 0.0
c.1581_1582insC
Sequence Walker   		i6295830,6295831c 6295804 694 6295110 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
c.1581_1582insC
Sequence Walker   		i6295830,6295831c 6295807 697 6295110 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
c.1581_1582insC
Sequence Walker   		i6295830,6295831c 6295809 699 6295110 6.7 6.7 0.0 1.0 100 -0.5 -0.5 0.0
c.1581_1582insC
Sequence Walker   		i6295830,6295831c 6295854 744 6295110 2.7 2.7 0.0 1.0 100 -1.3 -1.3 0.0
c.1584C>G
Sequence Walker   		c6295833g 6295804 694 6295110 1.4 1.4 0.0 1.0 100 -1.6 -1.6 0.0
c.1584C>G
Sequence Walker   		c6295833g 6295807 697 6295110 1.8 1.8 0.0 1.0 100 -1.5 -1.5 0.0
c.1584C>G
Sequence Walker   		c6295833g 6295809 699 6295110 6.7 6.7 0.0 1.0 100 -0.5 -0.5 0.0
c.1602C>G
Sequence Walker   		c6295851g 6295896 786 6295110 0.4 0.4 0.0 1.0 100 -1.9 -1.9 0.0
c.1611_1624del14
Sequence Walker   		d6295860,6295873 6295854 744 6295110 2.7 2.7 0.0 1.0 100 -1.3 -1.3 0.0
c.1611_1624del14
Sequence Walker   		d6295860,6295873 6295896 786 6295110 0.4 0.4 0.0 1.0 100 -1.9 -1.9 0.0
c.1839G>A
Sequence Walker   		g6296088a 6296063 953 6295110 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0
c.2254G>T
Sequence Walker   		g6296503t 6296477 -1243 6297720 3.4 3.4 0.0 1.0 100 -1.2 -1.2 0.0
c.2254G>T
Sequence Walker   		g6296503t 6296553 -1167 6297720 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0
c.2262_2263delCT
Sequence Walker   		d6296511,6296512 6296553 1443 6295110 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0
c.2315_2316insT
Sequence Walker   		i6296564,6296565t 6296553 -1167 6297720 0.2 0.2 0.0 1.0 100 -1.9 -1.9 0.0
c.2315_2316insT
Sequence Walker   		i6296564,6296565t 6296603 -1117 6297720 1.1 1.1 0.0 1.0 100 -1.7 -1.7 0.0
c.2455C>T
Sequence Walker   		c6296704t 6296739 -981 6297720 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0
c.2504_2505insC
Sequence Walker   		i6296753,6296754c 6296739 -981 6297720 0.5 0.5 0.0 1.0 100 -1.8 -1.8 0.0
c.2504_2505insC
Sequence Walker   		i6296753,6296754c 6296786 -934 6297720 0.0 0.0 0.0 1.0 100 -1.9 -1.9 0.0
c.2638_2643del6
Sequence Walker   		d6296887,6296892 6296914 1804 6295110 3.0 3.0 0.0 1.0 100 -1.3 -1.3 0.0
c.2638_2643del6
Sequence Walker   		d6296887,6296892 6296917 1807 6295110 0.4 0.4 0.0 1.0 100 -1.9 -1.9 0.0
c.2638_2643del6
Sequence Walker   		d6296887,6296892 6296923 1813 6295110 1.2 1.2 0.0 1.0 100 -1.7 -1.7 0.0
c.2642_2643delTC
Sequence Walker   		d6296891,6296892 6296923 1813 6295110 1.2 1.2 0.0 1.0 100 -1.7 -1.7 0.0
IVS4+1G>A
Sequence Walker   		g6283586a 6283580 -6 6283586 1.7 1.7 0.0 1.0 100 -1.6 -1.6 0.0