Gene: WFS1
mRNA Accession: AF084481
Mutation:WFS1.txt
Chromosome: chr 4

Sequence Walker  


Decrease of Information Content
Mutation SubmittedMutation InstructionGenomic CoordinatePosition Relative
to Natural Site		Closest
Natural Site		Initial(Ri)Final(Ri)Δ RiFold change% Binding (Final/Initial)Initial(Z)Final(z)Δ Z
c.397G>A
Sequence Walker 		g6283522a 6283533 -53 6283586 1.8 1.4 -0.3 -1.3 79.6 -1.6 -1.6 -0.1
c.397G>A
Sequence Walker   		g6283522a 6283530 -56 6283586 0.0 -0.3 -0.3 -1.0 NA -1.9 -2.0 -0.1
c.1046_1048delTCT
Sequence Walker 		d6295295,6295297 6295319 209 6295110 5.1 4.0 -1.0 -2.0 49.1 -0.8 -1.1 -0.2
c.1046_1048delTCT
Sequence Walker 		d6295295,6295297 6295320 210 6295110 3.0 2.3 -0.6 -1.6 64.3 -1.3 -1.4 -0.1
c.1046_1048delTCT
Sequence Walker 		d6295295,6295297 6295321 211 6295110 1.1 0.6 -0.5 -1.4 72.6 -1.7 -1.8 -0.1
c.1046_1048delTCT
Sequence Walker   		d6295295,6295297 6295302 192 6295110 0.5 -2.1 -2.6 -1.4 NA -1.8 -2.4 -0.6
c.1046_1048delTCT
Sequence Walker   		d6295295,6295297 6295313 203 6295110 1.1 -7.6 -8.7 -2.1 NA -1.7 -3.6 -1.9
c.1060_1062delTTC
Sequence Walker 		d6295309,6295311 6295319 209 6295110 5.1 2.7 -2.4 -5.2 19.2 -0.8 -1.4 -0.5
c.1060_1062delTTC
Sequence Walker 		d6295309,6295311 6295320 210 6295110 3.0 1.0 -2.0 -3.9 25.4 -1.3 -1.7 -0.4
c.1060_1062delTTC
Sequence Walker   		d6295309,6295311 6295313 203 6295110 1.1 -8.2 -9.3 -2.1 NA -1.7 -3.7 -2.0
c.1060_1062delTTC
Sequence Walker   		d6295309,6295311 6295321 211 6295110 1.1 -11.4 -12.5 -2.1 NA -1.7 -4.4 -2.7
c.1240_1242delTTC
Sequence Walker 		d6295489,6295491 6295492 382 6295110 2.7 0.8 -1.9 -3.7 27.1 -1.4 -1.8 -0.4
c.1240_1242delTTC
Sequence Walker 		d6295489,6295491 6295496 386 6295110 2.6 1.1 -1.4 -2.7 36.6 -1.4 -1.7 -0.3
c.1240_1242delTTC
Sequence Walker 		d6295489,6295491 6295511 401 6295110 4.6 3.7 -0.9 -1.9 53.8 -0.9 -1.1 -0.2
c.1240_1242delTTC
Sequence Walker   		d6295489,6295491 6295509 399 6295110 0.9 -3.8 -4.7 -1.9 NA -1.7 -2.8 -1.0
c.1243_1245delGTC
Sequence Walker   		d6295492,6295494 6295492 382 6295110 2.7 -4.9 -7.6 -6.4 NA -1.4 -3.0 -1.7
c.1328G>T
Sequence Walker   		g6295577t 6295577 467 6295110 4.5 -4.3 -8.7 -22.5 NA -1.0 -2.9 -1.9
c.1546_1548delTTC
Sequence Walker 		d6295795,6295797 6295799 689 6295110 3.8 2.9 -0.9 -1.8 55.0 -1.1 -1.3 -0.2
c.1546_1548delTTC
Sequence Walker 		d6295795,6295797 6295802 692 6295110 6.1 3.8 -2.3 -5.0 19.9 -0.6 -1.1 -0.5
c.1546_1548delTTC
Sequence Walker 		d6295795,6295797 6295803 693 6295110 1.0 0.1 -0.9 -1.9 53.2 -1.7 -1.9 -0.2
c.1546_1548delTTC
Sequence Walker 		d6295795,6295797 6295804 694 6295110 1.4 0.3 -1.1 -2.1 47.4 -1.6 -1.9 -0.2
c.1546_1548delTTC
Sequence Walker 		d6295795,6295797 6295807 697 6295110 1.8 0.8 -1.0 -1.9 51.6 -1.5 -1.8 -0.2
c.1546_1548delTTC
Sequence Walker 		d6295795,6295797 6295809 699 6295110 6.7 5.1 -1.6 -3.1 32.4 -0.5 -0.8 -0.4
c.1628T>G
Sequence Walker   		t6295877g 6295896 786 6295110 0.4 -0.7 -1.1 -1.3 NA -1.9 -2.1 -0.2
c.1637T>A
Sequence Walker   		t6295886a 6295896 786 6295110 0.4 -2.4 -2.8 -1.3 NA -1.9 -2.5 -0.6
c.1816G>C
Sequence Walker   		g6296065c 6296063 953 6295110 0.2 -0.2 -0.4 -1.2 NA -1.9 -2.0 -0.1
c.2006A>G
Sequence Walker 		a6296255g 6296253 1143 6295110 0.4 0.3 -0.0 -1.0 96.9 -1.9 -1.9 -0.0
c.2068T>C
Sequence Walker 		t6296317c 6296321 1211 6295110 3.1 2.4 -0.6 -1.5 64.5 -1.3 -1.4 -0.1
c.2068T>C
Sequence Walker 		t6296317c 6296331 1221 6295110 1.6 1.2 -0.4 -1.3 76.8 -1.6 -1.7 -0.1
c.2654C>T
Sequence Walker 		c6296903t 6296905 -815 6297720 4.9 3.2 -1.7 -3.2 31.6 -0.9 -1.2 -0.4
c.2654C>T
Sequence Walker   		c6296903t 6296903 -817 6297720 0.0 -1.4 -1.5 -1.0 NA -1.9 -2.2 -0.3
c.406C>T
Sequence Walker 		c6283531t 6283533 -53 6283586 1.8 0.1 -1.7 -3.2 31.6 -1.6 -1.9 -0.4
c.406C>T
Sequence Walker   		c6283531t 6283530 -56 6283586 0.0 -0.3 -0.3 -1.0 NA -1.9 -2.0 -0.1
c.670C>T
Sequence Walker 		c6286409t 6286411 41 6286370 4.9 3.3 -1.7 -3.2 31.6 -0.9 -1.2 -0.4
c.906C>A
Sequence Walker 		c6295155a 6295175 65 6295110 3.0 2.3 -0.7 -1.7 60.1 -1.3 -1.4 -0.2
c.906C>A
Sequence Walker 		c6295155a 6295180 70 6295110 1.8 1.4 -0.3 -1.3 78.8 -1.6 -1.6 -0.1
c.1038_1039insC
Sequence Walker 		i6295287,6295288c 6295287 177 6295110 4.6 3.7 -0.9 -1.9 52.2 -0.9 -1.1 -0.2
c.1038_1039insC
Sequence Walker 		i6295287,6295288c 6295290 180 6295110 7.5 5.3 -2.2 -4.5 22.1 -0.3 -0.8 -0.5
c.1096C>T
Sequence Walker 		c6295345t 6295347 237 6295110 4.1 2.4 -1.7 -3.2 31.6 -1.0 -1.4 -0.4
c.1230_1233delCTCT
Sequence Walker 		d6295479,6295482 6295492 382 6295110 2.7 0.7 -2.0 -4.0 24.7 -1.4 -1.8 -0.4
c.1230_1233delCTCT
Sequence Walker 		d6295479,6295482 6295496 386 6295110 2.6 2.2 -0.4 -1.3 74.1 -1.4 -1.5 -0.1
c.1230_1233delCTCT
Sequence Walker   		d6295479,6295482 6295483 373 6295110 1.4 -8.6 -10.0 -2.7 NA -1.6 -3.8 -2.2
c.1362_1377del16
Sequence Walker   		d6295611,6295626 6295619 509 6295110 3.0 -1.7 -4.8 -8.0 NA -1.3 -2.3 -1.0
c.1433G>A
Sequence Walker 		g6295682a 6295695 585 6295110 4.6 4.0 -0.5 -1.5 68.5 -0.9 -1.1 -0.1
c.1522_1536del15
Sequence Walker 		d6295771,6295785 6295799 689 6295110 3.8 3.3 -0.5 -1.4 71.8 -1.1 -1.2 -0.1
c.1522_1536del15
Sequence Walker 		d6295771,6295785 6295802 692 6295110 6.1 5.7 -0.4 -1.3 76.5 -0.6 -0.7 -0.1
c.1522_1536del15
Sequence Walker 		d6295771,6295785 6295803 693 6295110 1.0 0.4 -0.6 -1.5 67.3 -1.7 -1.8 -0.1
c.1525_1537del13
Sequence Walker 		d6295774,6295786 6295799 689 6295110 3.8 2.7 -1.1 -2.2 46.0 -1.1 -1.4 -0.2
c.1525_1537del13
Sequence Walker 		d6295774,6295786 6295802 692 6295110 6.1 5.8 -0.3 -1.2 82.5 -0.6 -0.7 -0.1
c.1525_1537del13
Sequence Walker 		d6295774,6295786 6295803 693 6295110 1.0 0.5 -0.5 -1.4 70.3 -1.7 -1.8 -0.1
c.1525_1537del13
Sequence Walker 		d6295774,6295786 6295804 694 6295110 1.4 0.6 -0.8 -1.7 57.3 -1.6 -1.8 -0.2
c.1525_1537del13
Sequence Walker 		d6295774,6295786 6295809 699 6295110 6.7 6.1 -0.6 -1.5 67.1 -0.5 -0.6 -0.1
c.1549delC
Sequence Walker 		d6295798,6295798 6295799 689 6295110 3.8 1.8 -2.0 -3.9 25.8 -1.1 -1.5 -0.4
c.1549delC
Sequence Walker 		d6295798,6295798 6295803 693 6295110 1.0 0.5 -0.6 -1.5 68.1 -1.7 -1.8 -0.1
c.1549delC
Sequence Walker 		d6295798,6295798 6295804 694 6295110 1.4 0.9 -0.5 -1.4 70.7 -1.6 -1.7 -0.1
c.1549delC
Sequence Walker 		d6295798,6295798 6295809 699 6295110 6.7 6.4 -0.3 -1.2 81.4 -0.5 -0.5 -0.1
c.1558C>T
Sequence Walker 		c6295807t 6295807 697 6295110 1.8 0.3 -1.5 -2.7 36.3 -1.5 -1.9 -0.3
c.1558C>T
Sequence Walker 		c6295807t 6295809 699 6295110 6.7 5.0 -1.7 -3.2 31.6 -0.5 -0.8 -0.4
c.1584C>G
Sequence Walker 		c6295833g 6295854 744 6295110 2.7 1.7 -1.0 -2.1 48.5 -1.3 -1.6 -0.2
c.1602C>G
Sequence Walker 		c6295851g 6295854 744 6295110 2.7 2.5 -0.2 -1.2 86.5 -1.3 -1.4 -0.0
c.1699_1704del6
Sequence Walker 		d6295948,6295953 6295964 854 6295110 4.8 2.0 -2.8 -6.8 14.7 -0.9 -1.5 -0.6
c.1699_1704del6
Sequence Walker 		d6295948,6295953 6295968 858 6295110 7.1 6.6 -0.5 -1.5 68.9 -0.4 -0.5 -0.1
c.1699_1704del6
Sequence Walker 		d6295948,6295953 6295969 859 6295110 1.7 1.6 -0.1 -1.1 91.1 -1.6 -1.6 -0.0
c.1699_1704del6
Sequence Walker   		d6295948,6295953 6295954 844 6295110 2.4 -6.8 -9.2 -5.3 NA -1.4 -3.4 -2.0
c.1699_1704del6
Sequence Walker   		d6295948,6295953 6295962 852 6295110 2.1 6.6 4.5 22.5 2245.4 -1.5 -0.5 1.0
c.1999C>T
Sequence Walker 		c6296248t 6296250 1140 6295110 3.1 1.5 -1.7 -3.2 31.6 -1.3 -1.6 -0.4
c.2002C>T
Sequence Walker 		c6296251t 6296250 1140 6295110 3.1 2.8 -0.3 -1.2 80.9 -1.3 -1.3 -0.1
c.2002C>T
Sequence Walker   		c6296251t 6296253 1143 6295110 0.4 -1.3 -1.7 -1.3 NA -1.9 -2.2 -0.4
c.2455C>T
Sequence Walker 		c6296704t 6296706 -1014 6297720 2.4 0.7 -1.7 -3.2 31.6 -1.4 -1.8 -0.4
c.2638_2643del6
Sequence Walker 		d6296887,6296892 6296905 1795 6295110 4.9 4.0 -0.8 -1.8 56.6 -0.9 -1.1 -0.2
c.2638_2643del6
Sequence Walker   		d6296887,6296892 6296903 1793 6295110 0.0 -0.2 -0.2 -1.0 NA -1.9 -2.0 -0.0
c.2642_2643delTC
Sequence Walker 		d6296891,6296892 6296905 1795 6295110 4.9 4.1 -0.7 -1.6 61.3 -0.9 -1.0 -0.2
c.2642_2643delTC
Sequence Walker 		d6296891,6296892 6296910 1800 6295110 6.1 5.2 -0.9 -1.8 55.4 -0.6 -0.8 -0.2
c.2642_2643delTC
Sequence Walker 		d6296891,6296892 6296913 1803 6295110 6.2 5.1 -1.1 -2.2 45.2 -0.6 -0.8 -0.3
c.2642_2643delTC
Sequence Walker 		d6296891,6296892 6296914 1804 6295110 3.0 1.5 -1.5 -2.9 34.4 -1.3 -1.6 -0.3
c.2642_2643delTC
Sequence Walker 		d6296891,6296892 6296917 1807 6295110 0.4 0.4 -0.0 -1.0 98.4 -1.9 -1.9 -0.0
c.2642_2643delTC
Sequence Walker   		d6296891,6296892 6296903 1793 6295110 0.0 4.1 4.1 17.3 1728.7 -1.9 -1.0 0.9
c.2648_2651delTCTT
Sequence Walker 		d6296897,6296900 6296905 1795 6295110 4.9 1.0 -3.8 -14.1 7.1 -0.9 -1.7 -0.8
c.2648_2651delTCTT
Sequence Walker 		d6296897,6296900 6296910 1800 6295110 6.1 4.0 -2.1 -4.2 23.5 -0.6 -1.1 -0.5
c.2648_2651delTCTT
Sequence Walker 		d6296897,6296900 6296913 1803 6295110 6.2 4.8 -1.4 -2.6 39.0 -0.6 -0.9 -0.3
c.2648_2651delTCTT
Sequence Walker 		d6296897,6296900 6296914 1804 6295110 3.0 1.7 -1.3 -2.5 40.0 -1.3 -1.6 -0.3
c.2648_2651delTCTT
Sequence Walker 		d6296897,6296900 6296923 1813 6295110 1.2 1.2 -0.0 -1.0 98.4 -1.7 -1.7 -0.0
c.2648_2651delTCTT
Sequence Walker   		d6296897,6296900 6296903 1793 6295110 0.0 -3.4 -3.5 -1.0 NA -1.9 -2.7 -0.8