Increase of Content

Gene:	NF1
mRNA Accession:	M82814
Mutation:	NF1.txt
Chromosome:	chr 17
Sequence Walker

No Change of Information Content
Mutation Submitted	Mutation Instruction	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)
1318C>T Sequence Walker	c29383213t	29383170	15	29383155	0.1	0.1	1.0	100	-2.4	-2.4
1318C>T Sequence Walker	c29383213t	29383226	71	29383155	3.3	3.3	1.0	100	-1.4	-1.4
1318C>T Sequence Walker	c29383213t	29383253	98	29383155	0.8	0.8	1.0	100	-2.2	-2.2
1381C>T Sequence Walker	c29383276t	29383226	-62	29383288	3.3	3.3	1.0	100	-1.4	-1.4
1381C>T Sequence Walker	c29383276t	29383253	-35	29383288	0.8	0.8	1.0	100	-2.2	-2.2
1381C>T Sequence Walker	c29383276t	29383288	0	29383288	8.6	8.6	1.0	100	0.2	0.2
1466A>G Sequence Walker	a29391440g	29391444	-58	29391502	0.5	0.5	1.0	100	-2.3	-2.3
1466A>G Sequence Walker	a29391440g	29391463	-39	29391502	4.7	4.7	1.0	100	-1.0	-1.0
1607C>A Sequence Walker	c29396000a	29396035	0	29396035	10.8	10.8	1.0	100	0.8	0.8
2033-2034insC Sequence Walker	i29401317,29401318c	29401269	-2081	29403350	2.4	2.4	1.0	100	-1.7	-1.7
2033-2034insC Sequence Walker	i29401317,29401318c	29401286	-2064	29403350	1.1	1.1	1.0	100	-2.1	-2.1
2033-2034insC Sequence Walker	i29401317,29401318c	29401302	-2048	29403350	4.6	4.6	1.0	100	-1.0	-1.0
247C>T Sequence Walker	c29335968t	29335921	-89	29336010	0.1	0.1	1.0	100	-2.4	-2.4
247C>T Sequence Walker	c29335968t	29336010	0	29336010	9.3	9.3	1.0	100	0.4	0.4
247C>T Sequence Walker	c29335968t	29336014	4	29336010	4.0	4.0	1.0	100	-1.2	-1.2
2540T>C Sequence Walker	t29406071c	29406037	97	29405940	0.6	0.6	1.0	100	-2.2	-2.2
2540T>C Sequence Walker	t29406071c	29406075	135	29405940	0.6	0.6	1.0	100	-2.2	-2.2
2540T>C Sequence Walker	t29406071c	29406079	139	29405940	1.1	1.1	1.0	100	-2.1	-2.1
278G>A Sequence Walker	g29335999a	29335971	-39	29336010	0.6	0.6	1.0	100	-2.2	-2.2
278G>A Sequence Walker	g29335999a	29336010	0	29336010	9.3	9.3	1.0	100	0.4	0.4
278G>A Sequence Walker	g29335999a	29336014	4	29336010	4.0	4.0	1.0	100	-1.2	-1.2
278G>A Sequence Walker	g29335999a	29336029	19	29336010	4.1	4.1	1.0	100	-1.2	-1.2
278G>A Sequence Walker	g29335999a	29336042	32	29336010	1.2	1.2	1.0	100	-2.1	-2.1
2875C>T Sequence Walker	c29406775t	29406732	-18	29406750	2.6	2.6	1.0	100	-1.6	-1.6
2970-2972delAAT Sequence Walker	d29403779,29403781	29403742	-3008	29406750	7.4	7.4	1.0	100	-0.2	-0.2
3193delC Sequence Walker	d29407837,29407837	29407825	-17	29407842	2.6	2.6	1.0	100	-1.6	-1.6
3193delC Sequence Walker	d29407837,29407837	29407842	0	29407842	7.5	7.5	1.0	100	-0.2	-0.2
3193delC Sequence Walker	d29407837,29407837	29407864	22	29407842	1.5	1.5	1.0	100	-2.0	-2.0
3193delC Sequence Walker	d29407837,29407837	29407870	28	29407842	2.5	2.5	1.0	100	-1.7	-1.7
3193delC Sequence Walker	d29407837,29407837	29407882	40	29407842	5.6	5.6	1.0	100	-0.7	-0.7
3274del40 Sequence Walker	d29409026,29409065	29409106	0	29409106	4.0	4.0	1.0	100	-1.2	-1.2
3277G>A Sequence Walker	g29409068a	29409106	0	29409106	4.0	4.0	1.0	100	-1.2	-1.2
3367G>T Sequence Walker	g29409668t	29409654	39	29409615	0.8	0.8	1.0	100	-2.2	-2.2
3367G>T Sequence Walker	g29409668t	29409672	57	29409615	4.6	4.6	1.0	100	-1.0	-1.0
3367G>T Sequence Walker	g29409668t	29409684	69	29409615	4.6	4.6	1.0	100	-1.0	-1.0
3520C>T Sequence Walker	c29409941t	29409924	7	29409917	1.3	1.3	1.0	100	-2.0	-2.0
3826C>T Sequence Walker	c29412644t	29412611	-78	29412689	0.3	0.3	1.0	100	-2.3	-2.3
3826C>T Sequence Walker	c29412644t	29412663	-26	29412689	2.0	2.0	1.0	100	-1.8	-1.8
3826C>T Sequence Walker	c29412644t	29412689	0	29412689	5.0	5.0	1.0	100	-0.9	-0.9
4084C>T Sequence Walker	c29426009t	29426013	-23	29426036	5.4	5.4	1.0	100	-0.8	-0.8
4084C>T Sequence Walker	c29426009t	29426015	-21	29426036	1.8	1.8	1.0	100	-1.9	-1.9
4084C>T Sequence Walker	c29426009t	29426036	0	29426036	7.7	7.7	1.0	100	-0.1	-0.1
4084C>T Sequence Walker	c29426009t	29426047	11	29426036	1.8	1.8	1.0	100	-1.9	-1.9
4537C>T Sequence Walker	c29438649t	29438609	-17	29438626	1.1	1.1	1.0	100	-2.1	-2.1
560G>A Sequence Walker	g29346887a	29346870	-44	29346914	0.7	0.7	1.0	100	-2.2	-2.2
560G>A Sequence Walker	g29346887a	29346880	-34	29346914	2.2	2.2	1.0	100	-1.8	-1.8
560G>A Sequence Walker	g29346887a	29346914	0	29346914	9.8	9.8	1.0	100	0.5	0.5
560G>A Sequence Walker	g29346887a	29346926	12	29346914	0.5	0.5	1.0	100	-2.3	-2.3
574C>T Sequence Walker	c29346901t	29346870	-44	29346914	0.7	0.7	1.0	100	-2.2	-2.2
574C>T Sequence Walker	c29346901t	29346880	-34	29346914	2.2	2.2	1.0	100	-1.8	-1.8
574C>T Sequence Walker	c29346901t	29346914	0	29346914	9.8	9.8	1.0	100	0.5	0.5
574C>T Sequence Walker	c29346901t	29346926	12	29346914	0.5	0.5	1.0	100	-2.3	-2.3
603-604insT Sequence Walker	i29357734,29357735t	29357691	-646	29358337	2.3	2.3	1.0	100	-1.7	-1.7
603-604insT Sequence Walker	i29357734,29357735t	29357698	-639	29358337	3.4	3.4	1.0	100	-1.4	-1.4
603-604insT Sequence Walker	i29357734,29357735t	29357747	-590	29358337	2.5	2.5	1.0	100	-1.7	-1.7
910C>T Sequence Walker	c29377359t	29377387	50	29377337	4.5	4.5	1.0	100	-1.1	-1.1
910C>T Sequence Walker	c29377359t	29377401	64	29377337	0.1	0.1	1.0	100	-2.4	-2.4
910C>T Sequence Walker	c29377359t	29377405	68	29377337	0.7	0.7	1.0	100	-2.2	-2.2
987-988insA Sequence Walker	i29376350,29376351a	29376354	-983	29377337	0.5	0.5	1.0	100	-2.3	-2.3
987-988insA Sequence Walker	i29376350,29376351a	29376377	-960	29377337	0.7	0.7	1.0	100	-2.2	-2.2
IVS16+3del6 Sequence Walker	d29400486,29400491	29400529	45	29400484	5.7	5.7	1.0	100	-0.7	-0.7
IVS16-6del4 Sequence Walker	d29400354,29400357	29400317	-42	29400359	3.1	3.1	1.0	100	-1.5	-1.5
IVS16-6del4 Sequence Walker	d29400354,29400357	29400333	-26	29400359	2.0	2.0	1.0	100	-1.8	-1.8
IVS26-2A>T Sequence Walker	a29409916t	29409885	-32	29409917	4.9	4.9	1.0	100	-0.9	-0.9
IVS26-2A>T Sequence Walker	a29409916t	29409889	-28	29409917	1.9	1.9	1.0	100	-1.9	-1.9
IVS26-2A>T Sequence Walker	a29409916t	29409924	7	29409917	1.3	1.3	1.0	100	-2.0	-2.0