All Mutations grouped

Gene:	NF1
mRNA Accession:	M82814
Chromosome:	chr 17
Sequence Walker

247C>T

Instruction: c29335968t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	29335970	-40	29336010	5.1	3.4	-1.7	-3.2	31.6	-0.8	-1.2	-0.4
Sites found for donor
No Change	29335921	-89	29336010	0.1	0.1	0.0	1.0	100	-2.4	-2.4	0.0
No Change	29336010	0	29336010	9.3	9.3	0.0	1.0	100	0.4	0.4	0.0
No Change	29336014	4	29336010	4.0	4.0	0.0	1.0	100	-1.2	-1.2	0.0
Decreased	29335971	-39	29336010	0.6	-1.0	-1.6	-1.5	NA	-2.2	-2.7	-0.5

278G>A

Instruction: g29335999a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29335970	-40	29336010	5.1	5.1	0.0	1.0	100	-0.8	-0.8	0.0
Sites found for donor
No Change	29335971	-39	29336010	0.6	0.6	0.0	1.0	100	-2.2	-2.2	0.0
No Change	29336010	0	29336010	9.3	9.3	0.0	1.0	100	0.4	0.4	0.0
No Change	29336014	4	29336010	4.0	4.0	0.0	1.0	100	-1.2	-1.2	0.0
No Change	29336029	19	29336010	4.1	4.1	0.0	1.0	100	-1.2	-1.2	0.0
No Change	29336042	32	29336010	1.2	1.2	0.0	1.0	100	-2.1	-2.1	0.0

560G>A

Instruction: g29346887a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29346859	-55	29346914	1.2	1.2	0.0	1.0	100	-1.7	-1.7	0.0
Sites found for donor
No Change	29346870	-44	29346914	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0
No Change	29346880	-34	29346914	2.2	2.2	0.0	1.0	100	-1.8	-1.8	0.0
No Change	29346914	0	29346914	9.8	9.8	0.0	1.0	100	0.5	0.5	0.0
No Change	29346926	12	29346914	0.5	0.5	0.0	1.0	100	-2.3	-2.3	0.0

574C>T

Instruction: c29346901t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	29346870	-44	29346914	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0
No Change	29346880	-34	29346914	2.2	2.2	0.0	1.0	100	-1.8	-1.8	0.0
No Change	29346914	0	29346914	9.8	9.8	0.0	1.0	100	0.5	0.5	0.0
No Change	29346926	12	29346914	0.5	0.5	0.0	1.0	100	-2.3	-2.3	0.0

603-604insT

Instruction: i29357734,29357735t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	29357756	-581	29358337	0.0	0.0	-0.0	-1.0	99.8	-1.9	-1.9	-0.0
No Change	29357774	-563	29358337	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	29357735	-602	29358337	7.3	-1.0	-8.3	-158.9	NA	-0.3	-2.1	-1.8
Sites found for donor
No Change	29357691	-646	29358337	2.3	2.3	0.0	1.0	100	-1.7	-1.7	0.0
No Change	29357698	-639	29358337	3.4	3.4	0.0	1.0	100	-1.4	-1.4	0.0
No Change	29357747	-590	29358337	2.5	2.5	0.0	1.0	100	-1.7	-1.7	0.0

910C>T

Instruction: c29377359t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29377337	0	29377337	5.7	5.7	0.0	1.0	100	-0.7	-0.7	0.0
No Change	29377354	17	29377337	0.6	0.6	0.0	1.0	100	-1.8	-1.8	0.0
Decreased	29377383	46	29377337	0.2	0.1	-0.1	-1.1	92.3	-1.9	-1.9	-0.0
Sites found for donor
No Change	29377387	50	29377337	4.5	4.5	0.0	1.0	100	-1.1	-1.1	0.0
No Change	29377401	64	29377337	0.1	0.1	0.0	1.0	100	-2.4	-2.4	0.0
No Change	29377405	68	29377337	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0

888del174

Instruction: d29359408,29359581 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	29359615	33	29359582	4.5	0.0	-4.5	-22.7	4.4	-1.0	0.0	1.0
increased	29359734	152	29359582	0.0	4.5	4.5	22.7	2271.6	0.0	-1.0	-1.0
Sites found for donor
Decreased	29359555	-27	29359582	1.0	-17.6	-18.7	-2.1	NA	-2.1	-7.8	-5.7
Decreased	29359582	0	29359582	11.4	0.0	-11.4	-2618.7	0.0	1.0	0.0	-1.0
Decreased	29359587	5	29359582	0.4	0.0	-0.4	-1.3	75.8	-2.3	0.0	2.3
Decreased	29359618	36	29359582	2.9	0.0	-2.9	-7.5	13.3	-1.6	0.0	1.6
increased	29359706	124	29359582	0.0	0.4	0.4	1.3	131.8	0.0	-2.3	-2.3
increased	29359737	155	29359582	0.0	2.9	2.9	7.5	747.7	0.0	-1.6	-1.6

987-988insA

Instruction: i29376350,29376351a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29376326	-1011	29377337	1.3	1.3	0.0	1.0	100	-1.7	-1.7	0.0
No Change	29376332	-1005	29377337	2.2	2.2	0.0	1.0	100	-1.5	-1.5	0.0
Decreased	29376365	-972	29377337	4.3	3.9	-0.5	-1.4	72.5	-1.0	-1.1	-0.1
No Change	29376397	-940	29377337	2.5	2.5	0.0	1.0	100	-1.4	-1.4	0.0
Sites found for donor
No Change	29376354	-983	29377337	0.5	0.5	0.0	1.0	100	-2.3	-2.3	0.0
No Change	29376377	-960	29377337	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0

1275G>A

Instruction: g29383170a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29383155	0	29383155	11.1	11.1	0.0	1.0	100	0.5	0.5	0.0
No Change	29383159	4	29383155	1.0	1.0	0.0	1.0	100	-1.7	-1.7	0.0
No Change	29383162	7	29383155	1.1	1.1	0.0	1.0	100	-1.7	-1.7	0.0
No Change	29383164	9	29383155	1.1	1.1	0.0	1.0	100	-1.7	-1.7	0.0
Sites found for donor
Decreased	29383170	15	29383155	0.1	-12.7	-12.8	-1.1	NA	-2.4	-6.3	-3.9

1318C>T

Instruction: c29383213t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	29383170	15	29383155	0.1	0.1	0.0	1.0	100	-2.4	-2.4	0.0
No Change	29383226	71	29383155	3.3	3.3	0.0	1.0	100	-1.4	-1.4	0.0
No Change	29383253	98	29383155	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0

1381C>T

Instruction: c29383276t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	29383226	-62	29383288	3.3	3.3	0.0	1.0	100	-1.4	-1.4	0.0
No Change	29383253	-35	29383288	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0
No Change	29383288	0	29383288	8.6	8.6	0.0	1.0	100	0.2	0.2	0.0

1466A>G

Instruction: a29391440g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	29391461	-41	29391502	1.1	0.5	-0.7	-1.6	62.7	-1.7	-1.8	-0.1
No Change	29391481	-21	29391502	1.1	1.1	0.0	1.0	100	-1.7	-1.7	0.0
Decreased	29391462	-40	29391502	0.2	-0.3	-0.4	-1.1	NA	-1.9	-2.0	-0.1
Decreased	29391463	-39	29391502	0.1	-0.2	-0.3	-1.0	NA	-1.9	-2.0	-0.1
Sites found for donor
No Change	29391444	-58	29391502	0.5	0.5	0.0	1.0	100	-2.3	-2.3	0.0
No Change	29391463	-39	29391502	4.7	4.7	0.0	1.0	100	-1.0	-1.0	0.0
increased	29391440	-62	29391502	-6.6	6.2	12.8	75.2	7522.0	-4.4	-0.5	3.9

1465-1466insC

Instruction: i29389901,29389902c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	29389918	-1448	29391366	0.1	0.2	0.1	1.1	105.1	-1.9	-1.9	0.0
No Change	29389950	-1416	29391366	1.2	1.2	0.0	1.0	100	-1.7	-1.7	0.0
increased	29389903	-1463	29391366	-0.0	2.9	2.9	7.3	729.4	-1.9	-1.3	0.6
Sites found for donor

1570G>T

Instruction: g29395963t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29395998	78	29395920	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
No Change	29396011	91	29395920	1.8	1.8	0.0	1.0	100	-1.5	-1.5	0.0
increased	29395975	55	29395920	-1.3	0.7	2.0	1.6	162.0	-2.2	-1.8	0.4
Sites found for donor

1607C>A

Instruction: c29396000a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	29395998	-37	29396035	2.0	2.4	0.5	1.4	138.3	-1.5	-1.4	0.1
Decreased	29396011	-24	29396035	1.8	-0.2	-2.0	-3.5	NA	-1.5	-2.0	-0.4
Sites found for donor
No Change	29396035	0	29396035	10.8	10.8	0.0	1.0	100	0.8	0.8	0.0
increased	29395998	-37	29396035	-4.5	0.3	4.8	1.2	123.3	-3.8	-2.3	1.5

IVS12a+1G>T

Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Unprocessed due to the following error. IVS12a+1G>T the old base at 29272226 is NOT g! It is a.

2033-2034insC

Instruction: i29401317,29401318c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	29401325	-2025	29403350	5.5	6.3	0.8	1.7	171.4	-0.7	-0.6	0.2
Increased	29401334	-2016	29403350	9.8	9.9	0.0	1.0	101.2	0.2	0.2	0.0
No Change	29401361	-1989	29403350	4.3	4.3	0.0	1.0	100	-1.0	-1.0	0.0
No Change	29401367	-1983	29403350	1.6	1.6	0.0	1.0	100	-1.6	-1.6	0.0
Sites found for donor
No Change	29401269	-2081	29403350	2.4	2.4	0.0	1.0	100	-1.7	-1.7	0.0
No Change	29401286	-2064	29403350	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0
No Change	29401302	-2048	29403350	4.6	4.6	0.0	1.0	100	-1.0	-1.0	0.0

2540T>C

Instruction: t29406071c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	29406073	133	29405940	1.6	3.3	1.7	3.2	315.6	-1.6	-1.2	0.4
Increased	29406074	134	29405940	0.9	1.2	0.3	1.2	121.4	-1.7	-1.7	0.1
Increased	29406093	153	29405940	2.1	2.1	0.0	1.0	103.5	-1.5	-1.5	0.0
No Change	29406122	182	29405940	1.2	1.2	0.0	1.0	100	-1.7	-1.7	0.0
Decreased	29406090	150	29405940	0.2	-0.1	-0.3	-1.1	NA	-1.9	-2.0	-0.1
Sites found for donor
No Change	29406037	97	29405940	0.6	0.6	0.0	1.0	100	-2.2	-2.2	0.0
No Change	29406075	135	29405940	0.6	0.6	0.0	1.0	100	-2.2	-2.2	0.0
No Change	29406079	139	29405940	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0

IVS16+3del6

Instruction: d29400486,29400491 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29400458	-26	29400484	1.2	1.2	0.0	1.0	100	-1.7	-1.7	0.0
Sites found for donor
Decreased	29400484	0	29400484	11.2	7.4	-3.7	-13.2	7.5	1.0	-0.2	-1.1
No Change	29400529	45	29400484	5.7	5.7	0.0	1.0	100	-0.7	-0.7	0.0

IVS16-6del4

Instruction: d29400354,29400357 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29400386	27	29400359	3.8	3.8	0.0	1.0	100	-1.1	-1.1	0.0
No Change	29400387	28	29400359	3.5	3.5	0.0	1.0	100	-1.2	-1.2	0.0
Decreased	29400359	0	29400359	5.9	-16.6	-22.6	-61.8	NA	-0.6	-5.6	-4.9
Sites found for donor
No Change	29400317	-42	29400359	3.1	3.1	0.0	1.0	100	-1.5	-1.5	0.0
No Change	29400333	-26	29400359	2.0	2.0	0.0	1.0	100	-1.8	-1.8	0.0
increased	29400351	-8	29400359	-5.8	0.7	6.5	1.6	162.5	-4.2	-2.2	2.0

2875C>T

Instruction: c29406775t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29406750	0	29406750	12.8	12.8	0.0	1.0	100	0.9	0.9	0.0
No Change	29406751	1	29406750	0.3	0.3	0.0	1.0	100	-1.9	-1.9	0.0
No Change	29406759	9	29406750	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
No Change	29406763	13	29406750	1.1	1.1	0.0	1.0	100	-1.7	-1.7	0.0
Increased	29406784	34	29406750	2.0	2.5	0.6	1.5	149.8	-1.5	-1.4	0.1
Sites found for donor
No Change	29406732	-18	29406750	2.6	2.6	0.0	1.0	100	-1.6	-1.6	0.0

2887C>T

Instruction: c29406787t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29406759	9	29406750	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
No Change	29406763	13	29406750	1.1	1.1	0.0	1.0	100	-1.7	-1.7	0.0
No Change	29406784	34	29406750	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
increased	29403792	-2958	29406750	-0.4	0.5	0.9	1.4	136.9	-2.0	-1.8	0.2
Sites found for donor

2970-2972delAAT

Instruction: d29403779,29403781 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	29403742	-3008	29406750	7.4	7.4	0.0	1.0	100	-0.2	-0.2	0.0
Decreased	29403776	-2974	29406750	2.4	-4.6	-7.0	-5.4	NA	-1.7	-3.8	-2.1

3193delC

Instruction: d29407837,29407837 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	29407825	-17	29407842	2.6	2.6	0.0	1.0	100	-1.6	-1.6	0.0
No Change	29407842	0	29407842	7.5	7.5	0.0	1.0	100	-0.2	-0.2	0.0
No Change	29407864	22	29407842	1.5	1.5	0.0	1.0	100	-2.0	-2.0	0.0
No Change	29407870	28	29407842	2.5	2.5	0.0	1.0	100	-1.7	-1.7	0.0
No Change	29407882	40	29407842	5.6	5.6	0.0	1.0	100	-0.7	-0.7	0.0

3277G>A

Instruction: g29409068a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29409046	-60	29409106	1.0	1.0	0.0	1.0	100	-1.7	-1.7	0.0
No Change	29409049	-57	29409106	9.8	9.8	0.0	1.0	100	0.2	0.2	0.0
No Change	29409056	-50	29409106	3.4	3.4	0.0	1.0	100	-1.2	-1.2	0.0
No Change	29409106	0	29409106	0.6	0.6	0.0	1.0	100	-1.8	-1.8	0.0
No Change	29409116	10	29409106	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
Sites found for donor
Increased	29409066	-40	29409106	5.7	6.1	0.4	1.3	131.9	-0.7	-0.6	0.1
No Change	29409106	0	29409106	4.0	4.0	0.0	1.0	100	-1.2	-1.2	0.0

3274del40

Instruction: d29409026,29409065 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29409106	0	29409106	0.6	0.6	0.0	1.0	100	-1.8	-1.8	0.0
No Change	29409116	10	29409106	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	29409046	-60	29409106	1.0	-19.2	-20.3	-2.0	NA	-1.7	-6.1	-4.4
Decreased	29409049	-57	29409106	9.8	-17.5	-27.3	-920.7	NA	0.2	-5.8	-6.0
Decreased	29409056	-50	29409106	3.4	-26.3	-29.7	-10.6	NA	-1.2	-7.7	-6.5
Sites found for donor
Decreased	29409066	-40	29409106	5.7	1.3	-4.4	-21.1	4.7	-0.7	-2.0	-1.3
No Change	29409106	0	29409106	4.0	4.0	0.0	1.0	100	-1.2	-1.2	0.0

IVS19b-3C>G

Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Unprocessed due to the following error. IVS19b-3C>G the old base at 29272228 is NOT c! It is g.

3367G>T

Instruction: g29409668t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29409654	39	29409615	2.5	2.5	0.0	1.0	100	-1.4	-1.4	0.0
Sites found for donor
No Change	29409654	39	29409615	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0
No Change	29409672	57	29409615	4.6	4.6	0.0	1.0	100	-1.0	-1.0	0.0
No Change	29409684	69	29409615	4.6	4.6	0.0	1.0	100	-1.0	-1.0	0.0
Decreased	29409668	53	29409615	0.9	-6.9	-7.8	-1.8	NA	-2.2	-4.5	-2.4

3520C>T

Instruction: c29409941t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29409912	-5	29409917	0.0	0.0	0.0	1.0	100	-1.9	-1.9	0.0
No Change	29409917	0	29409917	5.5	5.5	0.0	1.0	100	-0.7	-0.7	0.0
No Change	29409923	6	29409917	2.3	2.3	0.0	1.0	100	-1.4	-1.4	0.0
Sites found for donor
No Change	29409924	7	29409917	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0

3826C>T

Instruction: c29412644t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	29412647	-42	29412689	1.7	1.4	-0.3	-1.2	82.3	-1.6	-1.6	-0.1
Increased	29412654	-35	29412689	2.1	2.8	0.7	1.6	160.4	-1.5	-1.3	0.1
No Change	29412688	-1	29412689	2.7	2.7	0.0	1.0	100	-1.3	-1.3	0.0
Sites found for donor
No Change	29412611	-78	29412689	0.3	0.3	0.0	1.0	100	-2.3	-2.3	0.0
No Change	29412663	-26	29412689	2.0	2.0	0.0	1.0	100	-1.8	-1.8	0.0
No Change	29412689	0	29412689	5.0	5.0	0.0	1.0	100	-0.9	-0.9	0.0

4084C>T

Instruction: c29426009t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29425980	-56	29426036	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
No Change	29425991	-45	29426036	8.6	8.6	0.0	1.0	100	-0.1	-0.1	0.0
No Change	29426005	-31	29426036	0.4	0.4	0.0	1.0	100	-1.8	-1.8	0.0
Increased	29426013	-23	29426036	3.6	4.2	0.6	1.5	154.9	-1.1	-1.0	0.1
No Change	29426035	-1	29426036	4.5	4.5	0.0	1.0	100	-0.9	-0.9	0.0
No Change	29426047	11	29426036	3.5	3.5	0.0	1.0	100	-1.2	-1.2	0.0
Sites found for donor
No Change	29426013	-23	29426036	5.4	5.4	0.0	1.0	100	-0.8	-0.8	0.0
No Change	29426015	-21	29426036	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0
No Change	29426036	0	29426036	7.7	7.7	0.0	1.0	100	-0.1	-0.1	0.0
No Change	29426047	11	29426036	1.8	1.8	0.0	1.0	100	-1.9	-1.9	0.0

IVS26-2A>T

Instruction: a29409916t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29409912	-5	29409917	0.0	0.0	0.0	1.0	100	-1.9	-1.9	0.0
Increased	29409923	6	29409917	2.3	4.3	2.0	3.9	391.8	-1.4	-1.0	0.4
Decreased	29409917	0	29409917	5.5	-1.9	-7.4	-45.9	NA	-0.7	-2.4	-1.6
increased	29409934	17	29409917	-0.6	0.5	1.1	1.4	142.5	-2.1	-1.8	0.2
Sites found for donor
No Change	29409885	-32	29409917	4.9	4.9	0.0	1.0	100	-0.9	-0.9	0.0
No Change	29409889	-28	29409917	1.9	1.9	0.0	1.0	100	-1.9	-1.9	0.0
No Change	29409924	7	29409917	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0

4537C>T

Instruction: c29438649t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	29438626	0	29438626	4.9	4.9	0.0	1.0	100	-0.9	-0.9	0.0
No Change	29438697	71	29438626	7.6	7.6	0.0	1.0	100	-0.3	-0.3	0.0
No Change	29438699	73	29438626	0.3	0.3	0.0	1.0	100	-1.9	-1.9	0.0
Sites found for donor
No Change	29438609	-17	29438626	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0

IVS27b-2A>T

Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Unprocessed due to the following error. IVS27b-2A>T the old base at 29272227 is NOT a! It is t.

4772del293

Instruction: d29441963,29442255 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

5033delG

Instruction: d29502996,29502996 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

5264C>G

Instruction: c29504473g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

5294C>A

Instruction: c29504503a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

5546G>A

Instruction: g29504755a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

5205del544

Instruction: d29502625,29503168 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

5567delT

Instruction: d29507232,29507232 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

5798delC

Instruction: d29511802,29511802 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

5839C>T

Instruction: c29511843t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

5896C>T

Instruction: c29511900t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

6577delGAGgta

Instruction: d29514491,29514496 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

6709C>T

Instruction: c29515008t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

6789-6792delTTAC

Instruction: d29508828,29508831 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

6792C>A

Instruction: c29515655a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

6858G>C

Instruction: g29515721c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

7096-7101del6

Instruction: d29512824,29512829 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

IVS39-12T>A

Instruction: t29513237a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

7201A>T

Instruction: a29526110t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

7285C>T

Instruction: c29527125t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

7486C>T

Instruction: c29529264t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

7884-7885delGT

Instruction: d29526300,29526301 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor

8016delA

Instruction: d29535504,29535504 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor